Scientists said Tuesday they had used stem cells to grow human heart tissue that contracted spontaneously in a petri dish -- marking progress in the quest to manufacture transplant organs.
A team from the University of Pittsburgh, Pennsylvania, used induced pluripotent stem (iPS) cells generated from human skin cells to create precursor heart cells called MCPs. iPS cells are mature human cells "reprogrammed" into a versatile, primitive state from which they can be prompted to develop into any kind of cell of the body.
The primitive heart cells created in this way were attached to a mouse heart "scaffold" from which the researchers had removed all mouse heart cells, they wrote in the journal Nature Communications. The scaffold is a network of non-living tissue composed of proteins and carbohydrates to which cells adhere and grow on.
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